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UK Islet Autoantibody Registry

Recruitingn/aAges 6 Months - 70 YearsAllUniversity of Oxford
NCT07125365 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Type 1 diabetes (T1D) is a life-long condition where the immune system destroys part of the body (the pancreas) which makes the chemical, insulin. Insulin is needed to control blood sugar levels. Treatment involves life-long insulin replacement by injection or insulin pump. Previous research has shown that the development of T1D occurs through different stages. This starts with a phase where there are no symptoms, which can last months or years, before symptoms of T1D develop and a person becomes unwell. The risk of developing T1D increases with presence of markers in the blood called islet autoantibodies. The risk of developing T1D increases with presence of markers in the blood called islet autoantibodies (IAb). Children with two or more IAb have an 80-90% chance of developing T1D within 15 years. It is almost certain that they will develop the condition in their lifetime. Children wi

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or female, aged 6 months - 70 years * IAb positive (≥ 1) to any of the following: insulin/GAD/IA2/ZnT8, confirmed in a reference laboratory. * Participant is willing and able to give informed consent for participation in the study (≥ 16 years old), or for \< 16 years, parental/guardian consent (plus assent, where appropriate) * Living in the UK * For ADDRESS-2 participants only: have taken part in a blood draw as part of ADDRESS-2 * For the qualitative interviews: Have been living with (or is a parent/guardian of a child who has been living with) a positive IAb result for ≥ 6 months. Exclusion Criteria: * Ongoing subcutaneous insulin requirement
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What it tests

  • Not listed
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Where

1 site
University of Oxford
Oxford, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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