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Efficacy and Safety Evaluation of Ruscus Aculeatus L in Patients With Hemorrhoids

RecruitingPhase 4Ages 18 Years - 45 YearsAllSultan Abdulhamid Han Training and Research Hospi…
NCT07128979 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Hemorrhoidal disease is characterized by distal displacement and deterioration of structural integrity of vascular cushions in the anal canal, which physiologically help defecation and continence. Unlike advanced stage (stage IV) hemorrhoids, which require surgical intervention, various topical agents (gels, ointments, creams), oral venoactive drugs, homeopathic and phytotherapeutic products and nutritional supplements are widely used in stage II and III hemorrhoidal disease. The genus Ruscus (family Asparagaceae) is a group of plants native to the Mediterranean basin, Southern and Western Europe, and Iran, represented by perennial, rhizome-based, and evergreen shrubs. Among the species belonging to this genus, Ruscus aculeatus L. has the widest distribution area. The subsoil parts of the Ruscus plant are rich in steroidal saponins and show vasoconstrictor, diuretic, anti-inflammatory an

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients between the ages of 18-45 with complaints (symptomatic) consistent with hemorrhoidal disease 2. Patients with Stage II and III hemorrhoids according to the Goligher Hemorrhoid Rating system using physical examination (digital rectal examination, anoscopy/rectoscopy performed within a maximum of four weeks before the examination) 3. Patients who have signed the Informed Consent Form Exclusion Criteria: * Patients aged \<18 and \>45 years * Stage I and IV hemorrhoids according to the Goligher Hemorrhoid Rating system * Surgery for hemorrhoids at any time * Injection treatment for multiple hemorrhoids in the last 3 years * Perianal sepsis, inflammatory bowel disease, colorectal malignancy, or pre-existing sphincter injury within the last 3 years * Immunodeficiency * In addition to hemorrhoids, patients with anal fissures and perianal fistulas detected by simultaneous physical examination or anoscopy/rectoscopy
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What it tests

  • Neoven 225 mg capsules
  • Placebo
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Where

1 site
Sultan Abdulhamid Training and Research Hospital
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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