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Investigation of the Role of Inflammatory Markers in the Early Detection of Cerebral Vasospasm, Delayed Cerebral Ischemia, and Meningitis Associated With External Cerebrospinal Fluid Drainage After Non-Traumatic Subarachnoid Hemorrhage - A Prospective Case-Control Study

Recruitingn/aAges 18 Years - anyAllTamas Vegh, MD
NCT07129603 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background Non-traumatic subarachnoid haemorrhage (SAH) is frequently complicated by delayed cerebral ischaemia (DCI) and by ventriculitis/meningitis when external CSF drains are used; bedside TCCD has limited accuracy for vasospasm detection, creating a need for early biomarkers. Objective To assess the predictive and diagnostic performance of IL-6, IL-1β, TNFα, procalcitonin (PCT), C-reactive protein (CRP) and adrenomedullin (ADM) measured in CSF and serum for vasospasm, DCI, and drain-associated ventriculitis/meningitis after SAH; to test whether combining biomarkers improves accuracy versus routine parameters; and to explore associations with admission and day-14 serum 25-hydroxy-vitamin D. Methods Prospective case-control study at the University of Debrecen (planned n≈100; enrolment 01-Nov-2024-31-Dec-2029). Adults with angiography-verified SAH requiring lumbar/ventricular drainag

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults (≥18 years). * Angiography-identifiable non-traumatic SAH (regardless of source). * Requires lumbar or ventricular drain as part of treatment. Exclusion Criteria: * Traumatic SAH. * Patient/legal representative does not consent. * Meningitis within 6 months prior to ictus. * Immunosuppressed state (disease or medications affecting WBC number/function).
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What it tests

  • Not listed
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Where

1 site
University of Debrecen, Department of Anesthesiology and Intensive Care
Debrecen, Hungary
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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