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The Effect of Transcutaneous Vagal Nerve Stimulation (tVNS) on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage

RecruitingNAAges 18 Years - 65 YearsAllMarshall Holland
NCT07131696 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The significance of developing a safe and effective therapy for aneurysmal subarachnoid hemorrhage (aSAH) patients suffering cerebral vasospasm (CVS) cannot be overstated. Vasospasm - a clamping down of normal arteries in the days following rupture - remains incredibly challenging to treat.1,2 Current drugs and minimally invasive surgical therapies are helpful, yet woefully insufficient. Symptomatic cerebral vasospasm afflicts about 30% of aneurysmal subarachnoid hemorrhage patients and nearly half will go on to suffer a stroke, despite aggressive medical care.1-3 The autonomic nervous system is a balance between sympathetic (fight or flight) and parasympathetic (rest and digest) influence with sympathetic overactivity and inflammation shown to play an important role in the development and severity of cerebral vasospasm.4,5,17-20 Prior studies of autonomic nervous system neuromodulation

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📋 Eligibility rules (as published)
Inclusion Criteria: * Provision of signed and dated informed consent * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or Female * 18-65 years of age * Diagnosed with Fisher grade 3 or 4 aneurysmal subarachnoid hemorrhage * Ability to undergo endovascular treatment of aneurysmal subarachnoid hemorrhage * For females of reproductive potential: negative pregnancy test at time of treatment. * Plan to undergo standard of care treatment and follow-up Exclusion Criteria: * Medically unfit to undergo endovascular treatment (e.g., Hunt Hess grade 5) * Does not provide consent * Posterior circulation aneurysmal subarachnoid hemorrhage * Initial aneurysm treatment after post bleed day 1
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What it tests

  • Transcutaneous Vagal Nerve Stimulation
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Where

1 site
UAB Hospital
Birmingham, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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