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A Language-Based Training Intervention to Enhance Cognitive Health in Community-Dwelling Older Adults

RecruitingNAAges 60 Years - anyAllNational Taiwan University Hospital
NCT07132281 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Taiwan is fast approaching a super-aged society, making it urgent to bolster cognitive health in otherwise healthy older adults. This integrated project tackles that need with a language-centered intervention grounded in predictive-coding and active-inference theory. Over 12 weeks, community-dwelling adults aged 65 + join small-group reading-and-writing workshops that train them to actively predict, monitor, and revise linguistic information. Ninety volunteers are randomly allocated to an active language-prediction group, a passive reading group, or a hobby board-game control. Before and after the course, researchers collect behavioural tests, EEG, fMRI, and AI-based speech-language analytics to quantify gains and transfer effects across cognition, emotion, and daily function.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged between 20 and 30 (healthy young adults) or aged 65 and above (healthy older adults). * Native Mandarin Chinese speakers who had no exposure to non-indigenous languages before the age of five. * Have completed at least a junior high school level of education. * Right-handed. * Have normal or corrected-to-normal vision (e.g., through glasses or contact lenses). * Able to fully participate in the entire assessment and intervention schedule (with no more than two missed intervention sessions). * Achieve a score of 23 or higher on the Montreal Cognitive Assessment (MoCA). Exclusion Criteria: * Participation in another cognitive intervention program within the past two months. * Cognitive intervention is not feasible due to dyslexia or physical illness. Meet the diagnostic criteria for Mild Cognitive Impairment (MCI) or dementia. * Presence of severe depression, or cognitive changes caused by other psychiatric, neurological disorders, or substance abuse, with symptoms that are unstable or interfere with functioning. * History of brain injury or neurological conditions (e.g., stroke, aneurysm). * Contraindications for MRI scanning, such as metal implants, pacemakers, or pregnancy. * Claustrophobia (an anxiety disorder characterized by panic symptoms or fear of panic attacks in enclosed spaces such as elevators, vehicles, tunnels, or airplane cabins). * Unable to undergo cognitive assessments due to visual or hearing impairments.
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What it tests

  • Language activities active inference
  • Language activities passive
  • Board Games
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Where

1 site
National Taiwan University
Taipei, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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