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Feasibility of Different Types of Exercise Training in Perimenopausal Females

RecruitingNAAges 40 Years - anyFemaleUniversity of Toronto
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In plain words

What the trial is, and whether it could suit you

Throughout the menopause transition, women experience many symptoms (i.e., hot flashes, night sweats) that can significantly reduce their quality of life. Moreover, their risk of heart disease increases substantially. The years before menopause called "perimenopause" present a critical window of intervention to alleviate menopause symptoms and improve health outcomes. Our team is therefore interested in comparing the potential benefits of different approaches including following the Health Canada guidelines (i.e., accumulating 150 min of moderate-to-vigorous aerobic physical activity weekly); performing high-intensity interval training (HIIT), which involves alternating periods of intense exercise with periods of rest; or stretching in perimenopause. As a first step towards this goal, this study will assess how easy and enjoyable the interventions are to follow over a 6-week period. The

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Biological females in early and late perimenopause. Menopausal stage will be defined according to the Stages of Reproductive Aging Workshop +10 (STRAW+10). According to STRAW+10, perimenopause is characterized by menstrual cycle irregularity, specifically defined as having bleeding in the previous 12 months but at least a 7-day difference from usual menstrual cycle length * Experiencing menopause symptoms (e.g., hot flashes, night sweats, joint stiffness) * Aged 40 years or older * Multiple risk factors for cardiometabolic disease, namely being sedentary (\<30 min of moderate-vigorous physical activity/week), having a BMI ≥25 kg/m2, and a waist circumference indicative of abdominal obesity, specific to BMI (e.g., BMI 25-29.9: WC: 90cm; BMI 30-34.9: WC: 105cm; BMI 35-35.9: WC:115cm). Exclusion Criteria: * History of reproductive surgeries including oophorectomy, hysterectomy, ablation or gender-affirming. * Diagnosis of cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver disease, cancer (except for non-melanoma skin cancer), respiratory disease (e.g., Chronic Obstructive Pulmonary Disease or severe or uncontrolled asthma), uncontrolled hyper- or hypogonadism (change in medication or dosage in last 6 months and with major symptoms), and/or Polycystic Ovary Syndrome * Major signs or symptoms (regardless of known diagnosis) of cardiovascular diseases, diabetes, or renal disease * The use of medication that could impact blood glucose * Pregnant or post-partum \<12 months, lactating or breast feeding within 3 months of the start of study * Recreational smoking (e.g., tobacco, smoking) * Actively engaging in a low-carbohydrate diet (e.g., ketogenic, Atkins) * Using transdermal hormones, taking exogenous hormones, or receiving exogenous hormones from other means (e.g., intrauterine device) * Significant weight loss (i.e., \>5 kg) in past 3 months or currently taking weight loss medications
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What it tests

  • Guidelines-based moderate-intensity continuous exercise
  • High-intensity interval training
  • Stretching exercise
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Where

1 site
Goldring Centre for High Performance Sport
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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