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Non-Invasive Interventions for Respiratory Recovery in Chronic Spinal Cord Injury

RecruitingNAAges 18 Years - 70 YearsAllThomas Jefferson University
NCT07135583 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Spinal cord injuries (SCI) can seriously affect a person's ability to breathe. This happens because the injury can damage the nerves that control the muscles used for breathing. As a result, people with SCI often face breathing problems, a higher risk of lung infections, and even early death. While breathing exercises can help strengthen these muscles, they often aren't intense enough to make a big difference, especially in people with long-term injuries. This research project is exploring a new way to improve breathing in people with chronic SCI. The goal is to "wake up" the remaining nerve pathways that still connect the brain and spinal cord to the breathing muscles. By doing this, the investigators hope to make breathing exercises more effective and improve overall respiratory health. The investigators are testing a combination of two non-invasive (non-surgical) techniques: Transc

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. adults 18 to 70 years of age (the latter to reduce likelihood of cardiovascular disease); 2. chronic SCI for ≥ 1 year at or below C-3 to T-8 3. incomplete SCI based on classification of incomplete-B, C or D 4. medically stable with clearance from physician 5. SCI due to non-progressive etiology 6. \>20% impairment in maximal inspiratory or expiratory pressure generation Exclusion Criteria: * Individuals will be excluded due to (1) current diagnosis of an additional neurologic condition (eg. multiple sclerosis or stroke) (2) loss of diaphragm EMG activity on forced respiratory tests; (3) severe illness or infection (4) non-healing decubitus ulcers (5) untreated bladder or urinary infections (6) cardiovascular disease (7) lung disease (8) active heterotopic ossification (9) uncontrolled hypertension; (10) severe neuropathic pain; (11) pregnancy (5) severe recurrent and uncontrolled autonomic dysreflexia (6) history of seizure disorder.
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What it tests

  • Active Comparator: Single Intervention 1
  • Active Comparator: Single Intervention 2
  • Respiratory Resistance Exercise
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Where

1 site
Thomas Jefferson University Center City Campus
Philadelphia, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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