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Sleeve Lobectomy Following Neoadjuvant Therapy in NSCLC

Recruitingn/aAges 18 Years - anyAllShanghai Chest Hospital
NCT07135856 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational, retrospective, multicenter cohort study is to evaluate the surgical and oncologic outcomes of sleeve lobectomy performed via minimally invasive (RATS/VATS) or open thoracotomy approaches in patients with non-small cell lung cancer (NSCLC) who have undergone neoadjuvant therapy, including chemotherapy, immunotherapy, or combination regimens. The main questions this study aims to answer are: * Does minimally invasive sleeve lobectomy result in comparable or improved perioperative and postoperative outcomes compared to open thoracotomy following neoadjuvant treatment in NSCLC? * Does surgical approach influence oncologic endpoints such as margin status, lymph node dissection, recurrence-free survival, and overall survival? This research addresses a critical gap in the thoracic oncology field by evaluating the safety, complexity, and efficacy of advanced surg

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Histologically confirmed NSCLC * Undergoing sleeve lobectomy with curative intent * Receipt of neoadjuvant therapy (chemotherapy, immunotherapy, target therapy, etc.) * Surgical approach: either minimally invasive (VATS or RATS) or open thoracotomy * Availability of complete perioperative and follow-up data (minimum 12-month follow-up or until death) * Signed informative consent Exclusion Criteria: * Sublobar resections (e.g., segmentectomy) or pneumonectomy * Absence of neoadjuvant therapy * Purely diagnostic surgical procedures * Incomplete medical records or lost to follow-up * Metastatic (stage IV) disease at time of surgery
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What it tests

  • Not listed
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Where

1 site
Shanghai Chest Hospital
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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