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OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

RecruitingPhase 3Ages 50 Years - 105 YearsAllAmgen
NCT07136012 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥50 years * Lp(a)≥ 200 nmol/L during screening * Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis Exclusion Criteria: * Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia) * Prior or planned arterial revascularization * History of major bleeding disorder
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What it tests

  • Olpasiran
  • Placebo
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Where

252 sites
Advanced Cardiovascular LLC
Alexander City, United States
University of Alabama Birmingham Saint Vincents Birmingham
Birmingham, United States
Birmingham Clinical Research
Birmingham, United States
Alliance For Multispecialty Research - Daphne
Daphne, United States
Eastern Shore Research Institute
Fairhope, United States
Heart Center Research LLC
Huntsville, United States
CB Flock Research Corporation
Mobile, United States
Phoenix Clinical
Phoenix, United States

…and 244 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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