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A Pilot Study to Evaluate Equol and Its Effects on Menopausal Symptoms Experienced by Women in Singapore

Recruitingn/aAges 40 Years - 60 YearsFemaleAng Seng Bin
NCT07136220 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main aim of this study is to evaluate the effect of equol on menopausal symptoms of women. Our hypothesis is that equol producers will have milder menopausal symptoms compared to non-equol producers. Equol is known as a metabolite produced by gut microbiota from soy-related diet and has estrogen-like activity compared to the isoflavones from soybean. Previous studies have shown that some women can produce equol from soy-related diet, but the others cannot because they don't have the bacteria which can metabolite daidzein in gut even if they take isoflavones thorough soybean products. This study will involve participants consuming a soy protein bar and collection of urine samples before and after its consumption.

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📋 Eligibility rules (as published)
Inclusion Criteria: \- Women aged 40-60 Exclusion Criteria: * Pregnant women * Allergy to Soy * Allergy to nuts * Consumed antibiotics within 7 days of the study * Has a history of autoimmune diseases * Has a history of thyroid disease * On medical treatment with hormone therapy, elective oestrogen receptors modulators * Consuming equol-containing supplements or food * Consuming painkillers * Consuming anti-depressants and/or sleeping pills
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What it tests

  • Consumption of soy protein bar
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Where

1 site
KK Women's and Children's Hospital
Singapore, Singapore
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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