Digital Assessment of Real-World Walking Activity in Pulmonary Hypertension: A Prospective Multicenter Trial

Inclusion Criteria: * Pulmonary hypertension confirmed by right heart catheterization * Presence of precapillary pulmonary hypertension at time of recruitment, defined as mean pulmonary arterial pressure (MAP) ≥ 20 mmHg, pulmonary arterial wedge pressure (PAWP) ≤ 15 mmHg and pulmonary vascular resistance (PVR) \> 2 Wood units (160 dyn·s·cm-5) * After the right heart catheterization another follow-up visit is required in 3, 6, or 12 months * Independent walking without assistance and a 6-min walking distance \> 100m * WHO Functional Class I-III * Ability to provide informed consent and to participate in the study procedures * Willingness to wear the Axivity AX6 Sensor for 7 days Exclusion Criteria: * Hospitalization for a pulmonological disease within the 30 days prior to study recruitment * Neurological or orthopedic disease which limits walking ability * Acute pain which limits walking ability * Poor vision, which limits walking ability * Terminal illness with life expectancy \< 1 year * Ongoing treatment for malignancy * Acute psychosis or other severe psychiatric illness * Substance dependence