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Trehalose vs Glycine Air-Polishing in Peri-Implant Mucositis Treatment

RecruitingNAAges 18 Years - 70 YearsAllUniversity of Pavia
NCT07140146 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized controlled clinical trial investigates the effectiveness of trehalose powder compared to glycine powder when used in air-polishing during supportive therapy for peri-implant mucositis, a reversible inflammatory condition affecting the soft tissues around dental implants. A total of 40 adult patients with peri-implant mucositis will be enrolled and randomly assigned to receive non-surgical periodontal therapy combined with air-polishing using either trehalose powder (test group) or glycine powder (control group). Clinical parameters will be evaluated at baseline, 1 month, 3 months, and 6 months. These include Plaque Index (PI), Bleeding on Probing (BoP), Probing Pocket Depth (PPD), and Bleeding Score (BS), in order to assess plaque accumulation, inflammation, and bleeding. The primary objective is to compare the reduction in plaque levels between the two groups over the

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged between 18 and 70 years * Presence of peri-implant mucositis, defined as bleeding on probing (BoP) around implants without radiographic evidence of bone loss beyond initial remodeling * Visible biofilm on implant surfaces * Ability to understand and sign informed consent * Good oral hygiene and patient compliance * Availability for all follow-up visits (1, 3, and 6 months) Exclusion Criteria: * Presence of systemic conditions that may affect healing (e.g., uncontrolled diabetes, immunosuppression) * Current smokers or former smokers who quit less than 6 months ago * Pregnant or breastfeeding women * Use of antibiotics or anti-inflammatory drugs in the 3 months prior to baseline * Presence of peri-implantitis (i.e., bleeding on probing with concomitant radiographic bone loss) * History of head and neck radiotherapy * Presence of pacemakers or cardiac stimulators * Neurological or psychological disorders affecting study compliance
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What it tests

  • Trehalose Powder Air-Polishing
  • Glycine Powder Air-Polishing
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Where

1 site
Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia
Pavia, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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