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rTMS for Youth Inpatients With Depression

RecruitingNAAges 14 Years - 19 YearsAllSunnybrook Health Sciences Centre
NCT07140575 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Youth aged 15-24 are likelier to have depression than all age groups in Canada. One-third of depressed youth do not respond to psychotherapy and/or antidepressant medications. A treatment called repetitive transcranial magnetic stimulation or rTMS has proven helpful in adolescents and young adults whose depressive symptoms have been difficult to treat with psychotherapy and/or antidepressants. Unfortunately, youth find rTMS difficult to access because it is not funded by the Ontario Health Insurance Plan, is typically only offered to adults, and the treatment schedule usually involves once-daily sessions, 5 days/week, for 4-6 weeks, which is associated with travel and opportunity costs e.g. missing school. This project looks at the feasibility of a new treatment pathway that allows youth with difficult-to-treat depression in hospital to receive rTMS twice-daily while engaging in on-unit

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📋 Eligibility rules (as published)
Inclusion Criteria: * age 14-19 years * primary diagnosis of major depressive disorder or of bipolar I or II disorder, current episode depressed with no psychotic or mixed features * current episode of depression lasting at least 4 weeks * failed ≥1 evidence-based psychotherapy or antidepressant * have a GRID-HAMD-17 (17-item Hamilton Depression Rating Scale) score of ≥16 (moderate-severe range) * currently an inpatient or suitable for an elective inpatient admission Exclusion Criteria: * lifetime diagnosis of a psychotic disorder, anorexia nervosa, bulimia nervosa diagnosis of a substance use disorder (except caffeine and tobacco) within the past year * obsessive compulsive disorder or personality disorder that is the main source and driver of distress * active psychosis and/or mania * history of epilepsy or any other neurologic condition that includes a history of seizures * use of medications that lower the seizure threshold * pregnancy or nursing * history of severe headaches within the previous year * improvement in depressive symptom severity between screening and baseline by 25% or more * inability to adhere to the protocol
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What it tests

  • repetitive transcranial magnetic stimulation (rTMS)
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Where

1 site
Sunnybrook Health Sciences Centre
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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