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Efficacy of 810 nm Diode Laser Disinfection on Inflammatory Cytokines and Postoperative Pain After Endodontic Retreatment

RecruitingNAAges 20 Years - 40 YearsMaleAl-Azhar University
NCT07141459 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main cause of endodontic disorders is microbial infection. From the infected pulp tissue, microorganisms can penetrate into the deeper layers of root dentine and propagate a periapical tissue through the apical foramen and lateral canals causing apical periodontitis. Apical periodontitis is an inflammatory condition affecting the periapical area of teeth with a global prevalence of 52% among individuals and 5% at tooth level. At the periapical region, microbes and their products encounter the host immune defense. Innate immune cells combat bacteria through phagocytosis and release anti-microbial substances, while adaptive immune cells initiate both cell-mediated and humoral immune responses. This immune activation also stimulates osteoclasts, leading to bone resorption and creating space for the inflammatory cells' infiltration. During pulpal and periapical inflammation, neutrophils

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients have single-rooted teeth with root canal form type I. * Have previous endodontic therapy with failure. * Have periapical radiolucency (PAI score of 3 or 4). * Asymptomatic patients who had no pain or swelling had a negative response to palpation and percussion. * Patients who provide written informed consent. Exclusion Criteria: * Patients who had received antibiotic therapy within the past 3 months. Pregnancy and lactation. * Systemic disease. * Physical or mental disability. * Non restorable teeth. * Any signs of resorption, immature roots, fracture, sinus tract and dental anomaly
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What it tests

  • 810 nm diode laser disinfection
  • Calcium Hydroxide Intracanal medication
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Where

1 site
from the outpatient clinic of Endodontic Department, Faculty of Dental Medicine for Girls, Al-Azhar University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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