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Determination of Iron Absorption and Losses in People Living at High Altitude to Investigate the Requirements in This Population Group Using a Newly Developed Technique

RecruitingNAAges 18 Years - 45 YearsAllDiego Moretti
NCT07142590 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Iron is an essential micronutrient responsible for a whealth of biological processes of the human body. Iron plays a fundamental role especially in oxygen transport, by binding to hemoglobin in the blood circulation. Iron intake from the diet needs to be in balance the unavoidable losses that occur daily via different pathways. The recommended daily requirement of iron is based on the balance between absorption and losses and is calculated to maintain a balance so that the absorption equals losses. At higher altitudes, the absorption of iron may be higher due to adaptation mechanisms in response to low oxygen concentration, and to maintain a larger erytroid compartement. However, the long-term effects of altitude on iron balance are unknown. Filling this knowledge gap is important to better understand iron deficiency in populations living at high and moderate altitudes. Therefore, the in

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📋 Eligibility rules (as published)
Inclusion Criteria: * Females and males aged 18-45 y * BMI: 18 to 25 kg/m2 * Body weight \<70 kg for females, \<85 kg for males * Plasma ferritin \>25 µg/L * Signed informed consent Exclusion Criteria: * Hb \<12 g/dL (females), Hb \<13 g/dL (males), corrected for altitude using the 2024 WHO guidance values for hemoglobin adjustments * Inflammation (CRP \> 5 mg/L)1 * Plasma ferritin \>150 µg/L for females and \>200 µg/L for males * Chronic disease known to affect iron metabolism * Chronic medications (except for oral contraceptives) * Pregnancy (tested at screening) or intention to become pregnant during the course of the study * Lactation * High physical activity (MET-min/week \> 3000 calculated according to the IPAQ, short version, administered at the screening) * Difficulty with blood withdrawal * Earlier participation in a study using stable iron isotopes or participation in any clinical study within the last 30 days * Smoking * Blood donation, blood transfusion or significant blood loss (more than 400 mL) over the past 6 months * Intention to regularly donate blood during the 2 years duration of the study * No residence in the respective location/altitude for at least the last 2 years * No intention to reside in the respective location/altitude at least for the next 2 years * Participants who are planning to spend an extended period (\>12 weeks) at a different altitude from their residence location * Spending more than 2 nights per week at a different location from residence location * Inability to understand the information sheet and the informed consent form due to cognitive or language reasons
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What it tests

  • Stable Isotopes
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Where

1 site
Fernfachhochschule Schweiz (FFHS)
Zurich, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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