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Comparison of Surgical Management of Early Pregnancy Loss by Suction Curettage Versus Hysteroscopy in Patients Undergoing In-vitro Fertilization (IVF)

RecruitingNAAges 18 Years - 50 YearsFemaleAssaf-Harofeh Medical Center
NCT07143578 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Early pregnancy loss occurs in \~15% of pregnancies. The treatment options include surgical uterine evacuation by suction curettage, medical management with misoprostol, or conservative management without interventions. The advantages of surgical management include quick resolution of the pregnancy and avoidance of heavy vaginal bleeding, while the disadvantages include retained products of conception and intrauterine adhesion formation which could affect future fertility. With the aim of reducing the complications of suction curettage, uterine evacuation using operative hysteroscopy has been suggested. In a previous study, the investigators compared suction curettage with operative hysteroscopy for the surgical management of early pregnancy loss up to 10 weeks of gestation. The results showed significantly reduced adhesions rate (4.2% in the hysteroscopy group vs. 45.2% in the suction

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Diagnosis of early pregnancy loss up to 10 weeks' gestation, based on last menstrual period or ultrasound. 2. Pregnancy conceived through assisted reproductive techniques (in vitro fertilization, IVF). 3. Ability to provide informed consent, and proficiency in reading and writing Hebrew. Exclusion Criteria: 1. Heavy vaginal bleeding or diagnosis of incomplete abortion. 2. Signs of infection and/or suspicion of septic abortion 3. Known uterine anomalies- including septate, bicornuate, unicornuate, or didelphys uterus. 4. Prior medical or surgical treatment during the current pregnancy 5. History of intrauterine adhesions 6. History of ≥ 3 prior miscarriages. 7. History of ≥ 3 prior cesarean sections. 8. History of myomectomy via abdominal or hysteroscopic approach.
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What it tests

  • Operative hysteroscopy using tissue removal device
  • suction curettage
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Where

2 sites
Shamir Medical Center
Be’er Ya‘aqov, Israel
Sheba Medical Center, Tel Hashomer
Ramat Gan, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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