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Comparison of Milrinone and Epinephrine on TAPSE

RecruitingNAAges 18 Years - 70 YearsAllMansoura University
NCT07144267 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cardiopulmonary bypass (CPB) is a critical technology in cardiac surgery, allowing for the temporary replacement of the heart and lung functions during intricate surgical procedures. it has significant post-surgical complications, the most important complications of CPB is right ventricle (RV) dysfunction. Diagnosis and management of RV dysfunction is crucial for maintenance of hemodynamic stability and organ function in early post-operation period and prognostic for later phase.

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📋 Eligibility rules (as published)
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status II \& III * Age between 18 and 70 years * Both Gender * Body mass index less than 40 kg/m2 * Ejection fraction of \>40% * Tricuspid annular plane systolic excursion (TAPSE) \< 1.7cm Exclusion Criteria: * Patient refusal. * Preoperative RV impairment * Pulmonary hypertension (estimated pulmonary artery systolic pressure \> 50 mmHg) * Patients with any contraindications to Transesophageal echocardiography (TEE) * Redo or Re-exploration surgery * Patients with chronic kidney disease (serum creatinine \> 1.5 mg/ dl) * Patients with chronic liver disease (child pugh B and C)
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What it tests

  • Epinephrine
  • Milrinone Injection
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Where

1 site
Mansoura University Hospitals
Al Mansurah, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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