Induced Pluripotent Stem Cells-derived Small Extracellular Vesicles May Promote Neurological Function and Improve Cognitive Impairment in Acute Ischemic Stroke Patients

Inclusion Criteria: * Age ≥ 18 years old. * Diagnosed with acute ischemic stroke (AIS) according to WHO criteria. * Time from onset to enrollment ≤ 2 weeks (stable condition after admission and able to cooperate with cognitive assessment), accompanied by manifestations of cognitive impairment, with a score of \< 26 on the Montreal Cognitive Assessment (MoCA) scale. * Cerebral MRI or CT scan shows stroke lesions related to the condition. * Subjects or their family members voluntarily participate and sign the informed consent form. Exclusion Criteria: * A diagnosis of cognitive impairment prior to the onset of AIS; * Presence of aphasia, hearing impairment, visual impairment, dysarthria, or other conditions that prevent completion of neuropsychological assessments; * Patients with mental illnesses such as depression, anxiety disorder, or schizophrenia; * Patients with severe diseases of the heart, liver, lungs, kidneys, or other vital organs; * Patients with disturbed consciousness, a history of long-term alcohol consumption, a history of severe head trauma, or those who cannot cooperate with cognitive function tests for various reasons; * illiterate patients.