🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Perception of Pain During Gender Affirming Hormone Therapy

Recruitingn/aAges 18 Years - anyAllMedical University of Vienna
NCT07148921 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

It is known from the literature that women and men differ in their perception of pain. Why this is the case has not been conclusively clarified. Sex hormones could have a significant influence on this. The study team suspects that the classic hormone status of women is responsible for the lower pain threshold compared to men. People undergoing gender affirming therapy receive biologically opposite-sex hormones in order to adapt their external appearance as well as their voice, emotional life etc. to the desired gender. The aim of this study is to longitudinally record whether the intake of opposite-sex sex hormones leads to a change in pain and perception thresholds in this patient collective. To this end, potential study participants will be informed about the study and asked whether they would like to participate before the start of hormone therapy during their first visit to the tran

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * ≥ 18 years of age * Assigned female at birth (AFAB) * Diagnosed gender identity disorder/gender dysphoria and planned therapy with testosterone OR * ≥ 18 years of age * Assigned male at birth (AMAB) * Diagnosed gender identity disorder/ gender dysphoria and planned therapy with estradiol Exclusion Criteria: * Any sex hormone intake during the last 6 months * Acute or chronic pain * Polyneuropathy * Diagnosis of alcohol or drug addiction * BMI under 18 or over 35 * Pregnancy * Breastfeeding * Pharmacological analgesic therapy within the previous 7 days before each examination * History of significant trauma or surgery to the hands with residual neurological deficit or pain.
💊

What it tests

  • Quantitative Sensory Testing
  • Patient Health Questionnaire 9
  • Hormone concentrations
📍

Where

1 site
Mecial University of Vienna
Vienna, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy