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Topical Versus Injection PRP for Olfactory Dysfunction

RecruitingPhase 3Ages 18 Years - 80 YearsAllTaipei Veterans General Hospital, Taiwan
NCT07151703 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine whether two different delivery methods of autologous platelet-rich plasma (PRP) can improve olfactory function in adults with persistent olfactory dysfunction lasting more than three months. The main questions it aims to answer are: 1. Does carrier-assisted topical application of PRP lead to comparable or better improvement in smell function than intranasal injection of PRP? 2. Which method provides greater patient comfort and fewer adverse effects? Researchers will compare carrier-assisted topical PRP application to intranasal PRP injection to see if one approach is more effective in restoring olfactory function. Participants will: 1. Receive a single PRP treatment delivered either by injection or via a PRP-soaked carrier placed into the olfactory cleft. 2. Continue daily olfactory training for three months following the intervention.

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged between 18 and 80 years, regardless of sex * Subjective complaint of olfactory dysfunction with confirmed hyposmia or anosmia based on standardized olfactory testing * History of at least 3 months of prior olfactory training but with persistent olfactory complaints Exclusion Criteria: * Congenital anosmia * Diagnosed neurological or structural brain abnormalities (e.g., brain tumor, major head trauma, stroke) with low likelihood of olfactory recovery * Inability or unwillingness to comply with study procedures or follow-up assessments
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What it tests

  • Intranasal Injection of Autologous PRP
  • Carrier-Assisted Topical Application of Autologous PRP
  • platelet-rich plasma
  • olfactory training
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Where

1 site
Taipei Veterans General Hospital
Taipei, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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