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Clinical Efficacy and Mechanism of tDCS for Dysphagia in PD

RecruitingNAAges 18 Years - 100 YearsAllWang Ping
NCT07153692 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to verify transcranial direct current stimulation(tDCS) efficacy for Parkinson's disease (PD)-related dysphagia and its mechanism. Subjects are randomly split into two groups: control (sham tDCS + conventional dysphagia treatment) and experimental (real tDCS + conventional treatment). Assessments will be conducted at baseline, after the completion of intervention, and at the 3-month follow-up. Swallowing function will be evaluated via gold-standard videofluoroscopic swallowing study (VFSS) and scales. Resting-state functional magnetic resonance imaging (rs-fMRI) or functional near-infrared spectroscopy (fNIRS) will be measures for tracking changes in abnormal brain regions/networks. Correlations between swallowing recovery and brain function changes, plus group imaging differences, will reveal tDCS's neurophysiological mechanism.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Meet the Chinese Diagnostic Criteria for Parkinson's Disease (2016) or MDS Diagnostic Criteria for Multiple System Atrophy or Progressive Supranuclear Palsy; * VFSS examination indicates dysphagia; * Mini-Mental State Examination (MMSE) score \>23; * Willing to cooperate with the study and sign the informed consent form; Exclusion Criteria: * Comorbid with other diseases that cause dysphagia; * Comorbid with pneumonia, or severe cardiac/renal insufficiency; * Having metal implants in the body * With cognitive impairment or inability to cooperate.
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What it tests

  • tDCS
  • Conventional Dysphagia Treatment
  • sham tDCS
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Where

1 site
Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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