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Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Essen
NCT07154394 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits. Using Positron Emission Tomography (PET) scans with amyloid tracers - a conventional tool for non-invasively imaging amyloid deposits in Alzheimer's disease - the research will extend this imaging methodology to the heart. The study will conduct additional PET/MRI scans of the heart in patients undergoing amyloid tracer PET scans for Alzheimer's evaluations. Each participant will also undergo an echocardiogram and a clinical examination of dementia. This could potentially enhance diagnostic practices in both cardiac amyloidosis and Alzheimer's disease.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients undergoing cerebral amyloid PET examination for clinical indication to clarify Alzheimer's disease * No contraindications to undergo an MRI examination * No contraindications to undergo an Amyloid PET scan Exclusion Criteria: * Patients with vascular dementia and confirmed other causes of dementia (e.g. stroke, vitamin deficiency, thyroid insufficiency, toxic causes such as alcohol) * Patients with pronounced cardiac preconditions * Pregnant and breastfeeding women
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What it tests

  • Not listed
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Where

1 site
University Hospital Essen
Essen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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