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โ† Trials
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Efficacy of Methylprednisolone for Pain Control After ACL Repair

RecruitingPhase 4Ages 13 Years - 50 YearsAllSt. Louis University
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In plain words

What the trial is, and whether it could suit you

Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repair surgery to determine if this results in decreased postoperative pain and opioid use without increasing complications.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patient undergoing ACL repair or ACL reconstruction with tendon autograft * Age 13-50 years old * Able to provide informed consent or parent/legal guardian is able for minors Exclusion Criteria: * Concurrent and significant injury to other bones or organs (Injury Severity Score of 4 or greater) * Revision ACL reconstruction * Concomitant additional ligament reconstruction or high tibial osteotomy * A history of alcohol abuse, substance abuse or chronic opioid use (filled opioid medication ร—2 within 6 months of the surgery) * A history of renal failure (\<60 mL/min/1.73 m2), liver dysfunction (child class, \>B), severe heart disease (NYHA Class 4), diabetes, neurological or psychiatric diseases that may affect pain perception, and pre-existing immune suppression. * A history or active peptic ulcer disease, gastrointestinal bleeding, or current use of anticoagulation. * Patients currently taking oral or injectable glucocorticoids and those who have taken either within 1 month of the procedure. * Patients who are currently pregnant. * Patients who are unable to undergo the multimodal pain standardized protocol including those with comorbidities or medical allergies precluding the use of corticosteroids, gabapentin, hydrocodone, acetaminophen, ketorolac, and/or meloxicam.
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What it tests

  • Meloxicam 15 mg
  • Medrol 4 MG Oral Tablet Includes Medrol Dosepak
  • Gabapentin 300 mg
  • Hydrocodone 5Mg/Acetaminophen 325Mg Tab
  • Ketorolac 10 Mg Oral Tablet
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Where

1 site
Saint Louis University
St Louis, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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