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Obstructive Sleep Apnoea and Difficult Asthma (OSADA)

RecruitingNAAges 18 Years - 90 YearsAllSt. James's Hospital, Ireland
NCT07160868 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The OSADA (Obstructive Sleep Apnoea in Difficult Asthma) trial is an open-label, randomized control trial investigating the impact of diagnosing and treating obstructive sleep apnoea (OSA) on a asthma control in patients with difficult-to-control asthma. Participants will undergo home-based sleep studies to assess for OSA and are then allocated to one of three arms: 1) Patients with OSA treated with CPAP (intervention group), 2) Patients with OSA not treated for OSA (control group) and 3) Patients without OSA (reference group). The primary objective is to evaluate whether treating OSA improves asthma control, symptom burden, and quality of life compared to untreated OSA and to patients without OSA. Secondary outcomes include exacerbation rates, sleep quality, and healthcare utilization. This trial aims to clarify the contribution of OSA to poor asthma control and the potential benefit

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients must have a clinical diagnosis of asthma with supportive objective diagnostics including but not limited to, variable airflow obstruction, bronchial-hyper responsiveness and demonstrable eosinophilic inflammation via fractional exhaled nitric oxide or peripheral eosinophilia * Patients receiving step 4 or step 5 of 'The Global Initiative for Asthma' (GINA) treatment guidelines will be selected * Between the ages of 18 to 90 years of age Exclusion Criteria: * Patients with previous sleep study investigations * Excessive daytime sleepiness; ESS \>17 * Previous diagnosis of a sleep disorder * Resting hypoxaemia or need for long-term oxygen therapy * Inability to provide informed consent
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What it tests

  • Continuous positive airway pressure (CPAP)
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Where

1 site
St. James's Hospital
Dublin, Ireland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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