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Argon Plasma Coagulation Versus Endoscopic Mucosal Resection for Gastric Adenoma (CLER-GA)

RecruitingNAAges 20 Years - anyAllSamsung Medical Center
NCT07161479 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Gastric adenomas with low-grade dysplasia (LGD) are considered precancerous lesions of the stomach. While these lesions carry a lower risk of progressing to gastric cancer compared with high-grade dysplasia, there is still uncertainty about the best way to manage them. International medical guidelines differ in their recommendations, and for very small lesions (1 cm or smaller), some guidelines provide no clear direction. This creates uncertainty for both patients and physicians about whether to treat these lesions or simply observe them over time. Two endoscopic treatment methods are widely used in clinical practice: endoscopic mucosal resection (EMR) and argon plasma coagulation (APC). EMR involves lifting and cutting out the lesion. Its major advantage is that it removes the lesion completely and allows for detailed pathological examination. However, EMR can be technically more deman

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 20 years or older * Diagnosed with gastric adenoma with low-grade dysplasia measuring ≤ 1 cm on endoscopy * Scheduled to undergo endoscopic treatment * Able and willing to provide written informed consent Exclusion Criteria: * Previous treatment for gastric adenoma or gastric cancer * History of gastrectomy * Diagnosis of gastric cancer or high-grade dysplasia at the time of enrollment * Presence of multiple gastric adenomas * Pregnant, breastfeeding, or possibility of pregnancy * Uncontrolled chronic illnesses that may interfere with trial participation (e.g., uncontrolled hypertension, uncontrolled diabetes, chronic kidney disease, ascites, heart failure, psychiatric disorders)
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What it tests

  • Argon Plasma Coagulation (APC)
  • Endoscopic Mucosal Resection (EMR)
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Where

3 sites
National Cancer Center
Goyang-si, South Korea
Kangbuk Samsung hospital
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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