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A Study of AAVB-039 in Participants With Stargardt Disease (STGD1)

RecruitingPhase 1, Phase 2Ages 8 Years - 55 YearsAllAAVantgarde Bio Srl
NCT07161544 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of the 039-101 study is to evaluate the safety and tolerability of a single subretinal injection of AAVB-039 in participants with Stargardt disease secondary to a biallelic mutation of the ABCA4 gene. The study will also assess initial efficacy following AAVB-039 administration.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Molecular diagnosis of Stargardt disease due to ABCA4 mutation * Willingness to adhere to protocol per informed consent Exclusion Criteria: * Unwillingness to meet the requirements of the study * Participation in a clinical study with another Investigation Medicinal Product * Previous participation in another gene or cell therapy trial * Any condition that would preclude subretinal surgery * Complicating ocular and/or systemic diseases
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What it tests

  • AAVB-039
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Where

11 sites
Associated Retina Consultants
Phoenix, United States
Children's Hospital Los Angeles
Los Angeles, United States
Retina Vitreous Associates Medical Group
Los Angeles, United States
University of Florida Health Science Center
Jacksonville, United States
Mayo Clinic
Rochester, United States
Retina Consultants of Texas
Bellaire, United States
Retina Foundation of the Southwest
Dallas, United States
University of Utah
Salt Lake City, United States

…and 3 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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