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Early Versus Delayed Cholecystectomy After Percutaneous Cholecystostomy in Moderate and Severe Cholecystitis (ESCAPE)

RecruitingNAAges 20 Years - anyAllYada Suwan
NCT07161960 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Abstract: Acute cholecystitis (AC) is typically managed according to the 2018 Tokyo Guidelines, with treatment strategies determined by the severity of the disease, patient comorbidities, and hospital capabilities. In cases of moderate AC, treatment options include antibiotics with delayed laparoscopic cholecystectomy (LC), antibiotics with early LC, or antibiotics with percutaneous cholecystostomy (PCC) followed by delayed LC. However, the Toyo Guideline 2018 suggested that there is a lack of consensus regarding the optimal timing for surgery following PCC due to insufficient scientific evidence. In practice, delayed LC is often performed approximately 6 weeks after PCC insertion. While PCC can serve as a treatment option before definite surgery, complications such as tube dislodgment, obstruction, and failure to ambulate are common, leading to further hospital admissions and increase

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📋 Eligibility rules (as published)
Inclusion Criteria: * The patients are diagnosed moderate or severe from of acute cholecystitis according to Tokyo Guideline 2018. * PCC insertion was performed by body interventionists or surgeons. * Laparoscopic cholecystectomy will be performed in Maharaj Nakorn Chiang Mai Hospital, Lampang Hospital and Phrae Hospital. * Age equal or more than 20 years-old Exclusion Criteria: * The patients that suspected CBD stone and need to undergo EUS / ERCP. * Coincidence perihepatic abscess or liver abscess * The patients with active or severe underlying disease, whom specialists suggest to postpone an operation.
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What it tests

  • Laparoscopic cholecystectomy
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Where

1 site
Faculty of Medicine, Chiang Mai University 110 Inthawarorot Road, Sri Phum, Mueang, Chiang Mai 50200, Thailand
Chiang Mai, Thailand
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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