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Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men

RecruitingNAAges 18 Years - 44 YearsMaleIndiana University
NCT07161973 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a common clinical condition affecting untold millions of individuals each year. Such disuse leads to a rapid decline in muscle fiber area and hence whole muscle size, contributing to a decrease in strength, speed, and power as well as alterations in energy metabolism. Collectively, these changes lead to reduced physical function and contribute to the seriousness of any disease, illness (e.g., pneumonia), surgery (e.g., joint replacement), or injury (e.g., broken bone) accompanied by decreased muscular activity. Currently, there are no effective pharmacological treatments to prevent disuse-associated muscle wasting in humans. The above-described effects of disuse appear to be due, at least in

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men age 18-44 * Above the minimum threshold of the IPAQ questionnaire * Below the maximum threshold of the IPAQ questionnaire Exclusion Criteria: * Men and women \<18 or \>44 years of age * Unable to provide informed consent * Known clotting disorder * Previous history of deep vein thrombosis * Injury to either leg resulting in reduced mobility in the previous year * Currently dieting or weight instability for the past 3 months * Epileptic * Pacemaker or other implantable heart device * Currently taking antibiotics * Current smoker * Stage II hypertension (resting blood pressure \>140/\>90) * Previously undergone a revascularization procedure involving a vascular graft or stenting of the femoral or popliteal arteries * Those taking phosphodiesterase inhibitors (e.g., Viagra), proton pump inhibitors, antacids, xanthine oxidase inhibitors, hormonal contraceptives or on hormone replacement therapy * An answer of yes to any of the seven questions on the first page of the Physical Activity Readiness Questionnaire (PAR-Q. These exclusions include the following: * If participant's doctor has ever said that he/she has a heart condition and that he/she should only do physical activity recommended by a doctor * Pain in chest when doing physical activity * In past month, chest pain when not doing physical activity * If participant has ever lost balance because of dizziness or has ever lost consciousness * Muscle, bone, or joint problem that could be made worse by physical activity * Currently on prescribed drugs for blood pressure or heart condition. * If the participant knows of any other reason he/she should not do physical activity.
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What it tests

  • Beetroot Juice - Active
  • Placebo Beetroot Juice Without Nitrate
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Where

1 site
Indiana University Indianapolis
Indianapolis, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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