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Combined Gamma Knife/Linac Radiosurgery for Large Brain Tumors / Metastases

RecruitingPhase 2Ages 18 Years - anyAllSunnybrook Health Sciences Centre
NCT07162246 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

When cancer spreads to the brain, doctors often use a precise type of radiation therapy called stereotactic radiosurgery (SRS) to treat these tumors. This treatment can effectively control brain tumors while helping protect healthy brain tissue. However, when brain tumors or the areas where tumors were surgically removed are larger, treatment outcomes in terms of side effects and tumour control can become worse. Specifically, standard SRS on larger areas can have lower tumour control and higher risk of side effects, particularly a condition called radiation necrosis, which can cause swelling and damage in nearby healthy brain tissue. Currently at Sunnybrook, large brain tumors are typically treated with SRS spread over 5 daily treatments using a machine called a linear accelerator. While this approach works well for many patients, it may be possible to improve results by combining two d

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📋 Eligibility rules (as published)
Inclusion Criteria: * Presence of up to two large intracranial lesions * Up to 10 (previously untreated, or progressing after previous treatment) brain metastases at the time of enrollment on the diagnostic MRI (which includes the ILLs) to be treated with SRS/HSRS * Age =\> 18 years * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 * Expected survival \>3 months * Patients that are deemed suitable for both GK and Linac based treatment * Patients that are able to hold systemic cancer chemotherapy/immunotherapy at least 2 days prior and following an SRS fraction Exclusion Criteria: * Prior SRS to the ILLs * Prior WBRT, or plan for concurrent WBRT with the protocol treatment * Presence or history of any leptomeningeal/pachymeningeal disease * Metastatic disease within the ventricles of the brain or corpus callosum * Small cell, hematopoietic or germ cell primaries * Patient with absolutely contraindications for MRI * Severe symptoms that preclude MRI or treatment using standard procedures for Linac or GK * Pregnant or lactating patient * Inability or unwillingness to undergo informed consent or post-treatment follow-up
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What it tests

  • Radiation Therapy
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Where

1 site
Sunnybrook Health Sciences Centre
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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