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Effect of Mental Imagery in Patients With Persistent Post-concussion Symptoms

RecruitingNAAges 18 Years - 74 YearsAllReuth Rehabilitation Hospital
NCT07166536 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Mild Traumatic Brain Injury (mTBI) often results in persistent emotional, cognitive, and somatic symptoms-such as headaches and dizziness. These symptoms impose a significant burden, yet their underlying mechanisms remain unclear. Predictive processing theories suggest that persistent symptoms may result from learned perceptual errors, particularly in individuals with high negative affectivity. This framework may help explain ongoing persistent post-concussive symptoms (PPCS) in the absence of identifiable pathology, which have been linked to various psychological factors. Mental imagery (MI) is thought to engage similar predictive processes. There is evidence that MI of symptom-triggering movements may exacerbate symptoms in individuals with chronic somatic conditions. However, this phenomenon has not been studied in PPCS patients. Investigating symptom provocation through

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Current patients of Reut Rehabilitation Hospital or individuals who were discharged from the hospital within the past 12 months. 2. Diagnosis of mild Traumatic Brain Injury, concussion, blast injury, or cervical whiplash injury. 3. More than 3 months since the event. 4. Presence of headaches and/or dizziness that began after the injury and have persisted continuously or intermittently. 5. Exclusion of other potential causes of headaches, such as non-healed fractures, chronic inflammation/infection, increased intracranial pressure, or meningeal injury. 6. Headache intensity of at least 3/10 on the VAS scale. Exclusion Criteria: 1. Significant cognitive impairment preventing informed consent (Mini-Mental State Examination score \<20 or Montreal Cognitive Assessment score \<20, as per IRB requirements). 2. Diagnosed central neurological conditions such as multiple sclerosis, Parkinson's disease, stroke, or brain tumor. 3. Presence of known pyramidal or extrapyramidal neurological signs. 4. Significant language impairment interfering with communication. 5. Psychiatric disorders significantly affecting communication. 6. Use of vestibular-suppressant medication (e.g., Cinnarizine) with an inability or unwillingness to discontinue treatment 24 hours prior to testing. Withdrawal Criteria: 1\. Oculomotor dysfunction affecting multiple oculomotor functions.
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What it tests

  • Provocation Test for Symptoms Using Mental Imagery
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Where

1 site
Reuth Rehabilitation Hospital
Tel Aviv, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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