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The Impacts of Gluten-free Diet in Patients With Ankylosing Spondylitis

RecruitingNAAges 18 Years - 64 YearsAllSaglik Bilimleri Universitesi
NCT07166874 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Subclinical intestinal inflammation and intestinal permeability have been reported in patients with ankylosing spondylitis. Gluten is one of the main triggers of zonulin releaseand gluten intake may contribute to the development of the disease by increasing intestinal permeability. This study aims to determine the impacts of a gluten-freediet on intestinal permeability, sub-clinical intestinal inflammation, disease activity, functional status and quality of life in patients with ankylosing spondylitis. The main questions it aims to answer are: Does a gluten-free diet have an effect on disease activity and functional status in patients with ankylosing spondylitis? Does a gluten-free diet have an effect on intestinal permeability and subclinical intestinal inflammation in patients with ankylosing spondylitis? The investigators will evaluate the effects of the gluten-free diet compared to

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📋 Eligibility rules (as published)
Inclusion Criteria: * diagnosis of axial SpA defined by ASAS criteria * Adults (aged 18-64 years) * stable treatment (NSAID and/or DMARD) for at least 3 months * provide written informed consent and submit to the requirements of the study Exclusion Criteria: * Any diet at the time of inclusion or within 3 months prior to inclusion; * have a history of celiac disease; * have a history of Ulcerative Colitis, Crohn's Disease and Irritable Bowel Syndrom * patients with Type 1 and Type 2 Diabetes Mellitus * patients with Hashimoto Thyroiditis * are pregnant, breastfeeding, * patients who have used omega-3 and vitamins (A, C, E) regularly in the last 3 months. * BMI \<18,50 kg/m2 * BMI ≥29,99 kg/m2
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What it tests

  • Gluten Free Diet
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Where

4 sites
Bakırköy Dr. Sadi Konuk Training and Research hospital
Istanbul, Turkey (Türkiye)
İstanbul Medeniyet University
Istanbul, Turkey (Türkiye)
İstanbul Sağlık Bilimleri University
Istanbul, Turkey (Türkiye)
Marmara University
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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