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โ† Trials
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Anesthesia sTrategy foR Organ Procurement In braiN dEath

RecruitingPhase 3Ages 18 Years - anyAllUniversity Hospital, Grenoble
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In plain words

What the trial is, and whether it could suit you

The optimal anesthetic strategy during organ procurement in brain-dead donors remains unknown. The administration of anesthetic drugs in this setting aims to preserve hemodynamic stability in the face of reflex responses mediated by preserved spinal activity. Volatile anesthetics may blunt these reflexes, but their potential benefits in this context have never been investigated. This randomized trial evaluates the effects of volatile anesthesia (sevoflurane), opioid administration (sufentanil), or no anesthetic drugs on intraoperative hemodynamic stability during organ procurement in brain-dead donors. The primary outcome is the proportion of operative time within a predefined arterial blood pressure range.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Eligible adult brain-dead donor hospitalized in intensive care unit in one of the participating center: * Confirmed diagnosis of brain death according to French public health code. * Ongoing organ donation procedure managed by the local organ procurement coordination team with confirmation of the potential procurement of at least one intra-abdominal or intra-thoracic organ. * Transfer to the operating room for the organ procurement procedure scheduled for the next 6 hours and anesthesia team alerted. * Information of the patient's next of kin by the investigator and absence of opposition to research confirmed by the testimony of the next of kin according to French public health code. Exclusion Criteria: * Age \< 18 years. * DCD (donation after circulatory death) donors. * Ongoing extracorporeal circulation at the time of death. * Hemodynamic instability at the screening visit defined by a noradrenalin dose \> 1 ยตg/kg/min. * Contraindication to the implementation of the anesthetic interventions evaluated in the trial: * Prior history of opioid or volatil anesthetic agents allergy. * Prior personal or family history of malignant hyperthermia or history of myopathy at risk of malignant hyperthermia. * Opposition to the research expressed by the patient during his or her lifetime and documented by the next of kin.
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What it tests

  • Volatile anesthetic
  • Opioid Anesthesia
  • Intraoperative brain-dead donor management
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Where

1 site
CHU Grenoble Alpes
Grenoble, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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