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Exercise Rehabilitation for Cardiorenal Syndrome in HFrEF Patients

RecruitingNAAges 18 Years - 75 YearsAllHaiyan Pan
NCT07167368 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to investigate the efficacy and safety of exercise rehabilitation in patients with cardiorenal syndrome (CRS). Building on previous research demonstrating that exercise rehabilitation can effectively improve cardiac function and cardiopulmonary endurance in patients with chronic heart failure, this study will further explore its role in the context of CRS, a condition where such effects remain understudied. CRS patients typically exhibit reduced cardiopulmonary endurance, with significantly lower peak oxygen uptake (VO₂ peak) and 6-minute walk test (6MWT) distance compared to non-CRS patients. Adults aged 18-75 with chronic heart failure with reduced ejection fraction (HFrEF) complicated by chronic renal insufficiency will be enrolled and randomly assigned to two groups: 1. Basic treatment group: 30 patients receive only basic drug treatment for 6 months. 2. Exercise re

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with chronically stable HFrEF complicated by kidney dysfunction (eGFR \< 90 mL/min/1.73m²) * NYHA class II-III * Low risk in exercise risk assessment * Aged 18-75 years Exclusion Criteria: * Uncontrolled hypertension * Severe arrhythmias (including frequent ventricular premature contractions, ventricular tachycardia, rapid atrial fibrillation, sick sinus syndrome, and second-degree or higher atrioventricular block) * Obstructive hypertrophic cardiomyopathy * Moderate to severe stenotic valvular heart disease * Deep vein thrombosis or pulmonary embolism * History of syncope * Severe anemia * Abnormal thyroid function * Severe pulmonary diseases * Mental illnesses * Osteoarticular or muscular diseases that impede rehabilitation training
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What it tests

  • Standardized Basic Drug Therapy for HFrEF with Chronic Kidney Dysfunction
  • Home-based Personalized Exercise Rehabilitation
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Where

1 site
The Affiliated Hospital of Nantong University
Nantong, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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