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Identifying Genetic Targets in Gynecological Tumors

Recruitingn/aAges 18 Years - anyFemaleAzienda USL Reggio Emilia - IRCCS
NCT07169396 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This observational study aims to identfy genetic targets involved in the pathogenesis of gynecological tumors, with a focus on high-grade serous ovarian carcinoma. Using a triple approach - in silico, ex vivo and in vitro - the study will investigate the role of gonadotropins and their related signaling pathways in the epithelial ovarian cancers. Gene and protein expression levels will be evaluated through transcriptomic analysis, immunohistochemistry and functional assays on tumor cell lines. The goal is to uncover potential diagnostic or therapeutic targets in gynecological malignancies.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult women ≥18 years old * Histologically confirmed diagnosis of epithelial ovarian cancer (including high- grade serous, endometrioid, mucinous, clear cell, or mesonephric-like histotypes) * Signed informed consent (for prospective cases) or ethically approved waiver (for retrospective samples) Exclusion Criteria: * Refusal to sign informed consent * Diagnosis of low-grade or non-epithelial ovarian tumors * Patients whose clinical or pathological data are unavailable or insufficient for study inclusion
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What it tests

  • RNA extraction and gene expression
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Where

1 site
Azienda USL IRCCS di Reggio Emilia
Reggio Emilia, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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