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Postprandial Glucose Handing in Contraceptive and IUD Users

Recruitingn/aAges 18 Years - 45 YearsFemaleMcMaster University
NCT07169591 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Goals: The long-term use of hormonal birth control has been shown to effect glucose handling, or blood sugar regulation, and potentially lead to insulin resistance which increases a person's risk for metabolic diseases such as type 2 diabetes. The goal of this study is to investigate how the body handles glucose, in three groups of young, healthy females: NAT (naturally cycling, or not using hormonal birth control), OCP (taking a birth control pill), and IUD (using an intrauterine device). Objectives: We will investigate if the body's ability to handle glucose differs between these groups. We will also explore if these differences are linked to the levels of primary sex hormones in females, estrogen and progesterone, and if the synthetic versions produced by hormonal birth control have the same negative effect. We will use an oral glucose tolerance test to investigate these potential dif

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📋 Eligibility rules (as published)
Inclusion Criteria: * Within 18-45 years * BMI between 18.5 and 30.0 kg/m2 * Weight stable for the past 6 months (± 2kg) * VO2peak values within a below average to above average rangea * Fasting blood glucose \<6.0 mMb * Resting blood pressure \<140/90 mmHg NAT females: • Regular menstrual cycle for \> 6 months (defined as a cycle length of 21-35 days) OCP users: * Use of combined OCPs as prescribed for \> 3 months * Second generation levonorgestrel drugs only * Monophasic formulations only (Alesse, Alysena, Audrina, Aviane, Min-Ovral, Ovima, or Portia) IUD users: * Insertion of IUD no fewer than 3 months prior to beginning of study * Hormonal, levonorgestrel-releasing IUD (Kyleena or Mirena) Exclusion Criteria: * Smoking * Diabetes, cancer, or other metabolic disorders * Cardiac or gastrointestinal problems * Infectious disease * Barium swallow or nuclear medicine scan in the previous 3 weeks * Pregnant or breastfeeding * Diagnosis of polycystic ovary syndrome * Endometriosis * Use of emergency contraception (e.g., Plan B) within the previous 3 months NAT females: • Use of any type of hormonal contraceptive in the previous 3 months OCP users: * Not using OCP as prescribed (e.g. missing doses or taking drug inconsistently) * Use of OCP for longer than 3 years. IUD users: * Insertion of Kyleena IUD longer than 2 years. * Insertion of Mirena IUD longer than 4 years.
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What it tests

  • Oral Glucose Tolerance test (75g 2-hour)
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Where

1 site
McMaster University, Ivor Wynne Centre
Hamilton, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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