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EIT vs Dynamic Compliance Guided PEEP Titration During Laparoscopic Gynecological Surgery

RecruitingNAAges 18 Years - anyFemalePest County Flór Ferenc Hospital
NCT07170514 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this randomized controlled clinical trial is to compare the pulmonary protective effects of two different positive end-expiratory pressure (PEEP) titrating methods in patients with non-injured lungs undergoing laparoscopic gynecological surgery. Despite dynamic pulmonary compliance (Cdyn) guided lung protective ventilation has several proven advantages, the investigators hypothesize that optimizing intraoperative mechanical ventilation using electrical impedance tomography (EIT) may further improve patient outcomes, enhance postoperative recovery, shorten in-hospital stay and reduce healthcare related costs. The main questions aim to answer are: * May EIT-guided PEEP titration reduce the mechanical power of ventilation and improve oxygenation more significantly than the Cdyn-guided method? * What effect might a decrease in mechanical power of ventilation have on postoperat

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📋 Eligibility rules (as published)
Inclusion criteria: * Patient scheduled for elective laparoscopic gynaecological surgery * Age \> 18 years * Signed consent to participate in the trial Exclusion criteria: * Age \< 18 years * American Society of Anesthesiologists (ASA) physical status IV * History of severe restrictive or chronic obstructive pulmonary disease (COPD, Global Initiative for Chronic Obstructive Lung Disease grades III or IV) * Uncontrolled bronchial asthma * Pulmonary metastases * History of any thoracic surgery * Need for thoracic drainage before surgery * Congestive heart failure (NYHA grades III or IV) * Extreme obesity (BMI\>35 kg m-2) * Lack of patient's consent
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What it tests

  • EIT-guided PEEP titration
  • Cdyn-guided PEEP titration
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Where

3 sites
Semmelweis University
Budapest, Hungary
Semmelweis Hospital Kiskunhalas
Kiskunhalas, Hungary
Flór Ferenc Hospital Kistarcsa
Kistarcsa, Hungary
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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