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Long-Term Outcomes and Post-Intensive Care Syndrome: Investigating the Associations Between Metabolic Signatures and Physical Functioning in Critically Ill Patients

Recruitingn/aAges 18 Years - anyAllARH van Zanten, MD PhD
NCT07170527 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Despite being young, healthy, and physically fit, some intensive care unit (ICU) patients experience significantly worse functional recovery after critical illness than older patients with multiple comorbidities although a poor precondition seems to be associated with worse ICU outcomes. This paradox highlights a fundamental gap in our understanding of the determinants of long-term recovery. While nonmodifiable factors such as age and pre-existing disease explain part of the variation, they cannot fully account for the wide heterogeneity in outcomes. Metabolic disturbances during critical illness, such as hypercatabolism, impaired muscle metabolism, nutritional deficits, systemic inflammation, and disruption of gut health, are likely to influence recovery trajectories, yet remain poorly characterized. Because these processes represent potentially modifiable targets, combining their evalu

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years at time of ICU admission; * Received ventilatory support (IMV or NIV) within 48 hours after ICU admission with an expected duration of ≥48 hours during ICU stay (irrespective of ICU length of stay); OR * An expected ICU length of stay of ≥72 hours (irrespective of ventilatory support). Exclusion Criteria: * Concurrent participation in an intervention study with an anticipated therapeutic effect on PICS outcomes (physical functioning, cognitive functioning, or mental health status) * Pre-admission diagnosis of a progressive neurological disease (e.g., Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, progressive forms of multiple sclerosis) * Participants with neurological paralysis significantly affecting leg function (e.g., spinal cord injury, multiple sclerosis) * Patients receiving palliative care, with a life expectancy of \<3 months (e.g., hospice care or equivalent) * Patients who are moribund (i.e., in the final stages of a terminal illness, with imminent death expected) * Anticipated logistical limitations during recovery phase (e.g., transfer to another hospital, no fixed abode); * Deemed not suitable to participate based upon the judgement of the treating intensivist.
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What it tests

  • Not listed
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Where

1 site
Gelderse Vallei Hospital
Ede, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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