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โ† Trials
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The Impact of Transjugular Intrahepatic Portosystemic Shunt on Recompensation in Patients With Decompensated Liver Cirrhosis

Recruitingn/aAges 18 Years - 80 YearsAllUnion Hospital, Tongji Medical College, Huazhong โ€ฆ
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In plain words

What the trial is, and whether it could suit you

The traditional view holds that the natural course of cirrhosis is a unidirectional process, characterized by irreversible progression from the compensated stage to the decompensated stage, and is highly likely to develop further decompensation events or even death. However, a growing body of evidence suggests that the natural course of cirrhosis is not always unidirectional - after the removal of the etiology, the structural and functional changes of the liver may be partially reversed. This understanding has given rise to the concept of "liver recompensation," which has been standardized at the Baveno VII Consensus Conference. Notably, in a cohort of patients with alcohol-related cirrhosis, 18% achieved recompensation, which was significantly associated with a reduction of more than 90% in liver-related mortality. In patients with hepatitis B-related cirrhosis, 6% achieved recompensati

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Age between 18 and 80 years old; 2. Diagnosed with decompensated liver cirrhosis (diagnostic criteria: positive liver histopathological examination, or comprehensive judgment based on clinical symptoms, biochemical indicators and imaging features); 3. The etiology of liver cirrhosis is intervenable (including hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, alcoholic liver disease (ALD), etc.); 4. Patients with indications for Transjugular Intrahepatic Portosystemic Shunt (TIPS) treatment of cirrhotic portal hypertension, such as those with cirrhotic portal hypertension-related esophagogastric variceal bleeding refractory to endoscopic treatment, and patients with refractory ascites caused by cirrhotic portal hypertension; 5. Obtained informed consent signed by the patient or their family members. Exclusion Criteria: 1. Compensated liver cirrhosis at the time of TIPS treatment (without decompensated events such as ascites, hepatic encephalopathy, or esophagogastric variceal bleeding); 2. TIPS performed for the treatment of non-cirrhotic portal hypertension (e.g., idiopathic portal hypertension, Budd-Chiari syndrome, sinusoidal obstruction syndrome, etc.); 3. Patients complicated with malignant tumors such as hepatocellular carcinoma (HCC), renal cell carcinoma, or lung cancer prior to TIPS; 4. Patients with severe cardiopulmonary dysfunction or a Model for End-Stage Liver Disease (MELD) score \> 18; 5. Pregnant patients; 6. Patients with uncontrolled systemic infection or inflammation; 7. Patients with severe coagulation disorders; 8. Patients allergic to contrast medium. Criteria for Termination/Withdrawal from the Study: 1. Patients with Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedure failure due to various reasons; 2. Patients who voluntarily request to withdraw from the study.
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What it tests

  • Not listed
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Where

15 sites
Second Xiangya Hospital, Central South University
Changsha, China
The Third Xiangya Hospital of Central South University
Changsha, China
Fujian Medical University Union Hospital
Fuzhou, China
Huanggang Central Hospital
Huanggang, China
Jingzhou Central Hospital
Jingzhou, China
Jiangxi Provincial People's Hospital
Nanchang, China
The First Affiliated Hospital of Nanjing Medical University
Nanjing, China
Shengjing Hospital of China Medical University
Shenyang, China

โ€ฆand 7 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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