💬In plain words
What the trial is, and whether it could suit you
The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
For 30 patients with documented Type 2 diabetes
Inclusion Criteria:
* Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
* Age is \> or = 60 and \< or = 85 years of age
* Documented Type 2 diabetes
* Scoring 26 or higher on the MoCA test
Exclusion criteria:
* diagnosis of type 2 diabetes \< 1 year prior to enrollment
* HbA1c \<6.5% or \>10.0%
* body mass index \> 40 kg/m 2
* incident cardiovascular events in the last year (heart attack, stroke)
* symptomatic coronary artery disease and/or heart failure
* uncontrolled hypertension
* obstructive sleep apnea
* pulmonary disease
* dementia
* renal impairment with creatinine clearance (eGFR) of \<60 ml/min
* smoking or history of smoking within past one year
30 nondiabetic control subjects will also be studied.
Inclusion criteria:
* Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
* Age is \> or = 60 and \< or = 85 years of age
* Scoring 26 or higher on the MoCA test
Exclusion criteria:
* Diagnosis of diabetes (Type 1 or Type 2)
* body mass index \> 40 kg/m2
* incident cardiovascular events in the last year (heart attack, stroke)
* symptomatic coronary artery disease and/or heart failure
* uncontrolled hypertension
* obstructive sleep apnea
* pulmonary disease
* dementia
* renal impairment with creatinine clearance (eGFR) of \<60 ml/min
* smoking or history of smoking within past one year
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