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Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest

RecruitingPhase 2, Phase 3Ages 18 Years - anyAllGabriel Riva
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In plain words

What the trial is, and whether it could suit you

Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation. The survival decreases with number of defibrillations required to terminate VF/VT. In 2022, one prospective cluster randomized trial showed increased survival among (OHCA) patients in refractory VF using Double Sequential Defibrillation (DSD). If DSD can increase survival among all patients in VF that dont respond to one defibrillation, i.e. before it has become refractory is not known. The aim of this trial is to assess survival with a double defibrillation strategy initiated as soon as possible among patients with Out of Hospital Cardiac Arrest with initial shockable rhythm and at least one failed standard defibrillation, compared with continued resuscitation using standard defibrillation.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * OHCA patients with VT/VF at first rhythm analysis and at least one defibrillation performed in standard (A-L) position Exclusion Criteria: * Age \< 18 years * Obvious pregnancy * Known preexisting Do Not Attempt Resuscitation order
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What it tests

  • Double sequential defibirllation
  • Standard defibrillation
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Where

14 sites
ARREST (AmsteRdam REsuscitation STudies)
Amsterdam, Netherlands
Centro de Emergencias 061 Andalucía
Málaga, Spain
Médico Emergencias Osakidetza EMERGENTZIAK
Bilbao, Spain
Sistema de Emergencias Medicas de Catalunya
Barcelona, Spain
SUMMA 112 Emergency medical services
Madrid, Spain
Ambulanssjukvården, Region Halland
Halmstad, Sweden
Ambulanssjukvården Region Värmland
Karlstad, Sweden
Ambulanshelikoptern (HEMS) Västra Götalandsregionen
Kungälv, Sweden

…and 6 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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