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Association Between EIT and CT During PEEP Titration in Patients With Acute Respiratory Failure

Recruitingn/aAges 18 Years - anyAllIstituto Clinico Humanitas
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In plain words

What the trial is, and whether it could suit you

This observational study will analyze data already collected by the investigators as part of their routine clinical practice from patients with acute respiratory failure (ARF) treated with mechanical ventilation. The study itself does not require any specific intervention. Mechanical ventilation can save the lives of patients with ARF. However, if used improperly, it can exacerbate lung disease and worsen outcomes (Slutsky et al.). Despite decades of animal and clinical research, it remains unclear how to establish the positive end-expiratory pressure (PEEP) during mechanical ventilation to reduce the risk of lung damage. Several methods have been suggested, but none have consistently proven superior to the others (Sahetya et al.). As part of their routine clinical practice, the investigators study the responses to different PEEP levels of patients with ARF undergoing mechanical venti

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Adults (โ‰ฅ18 years of age) admitted to our Unit with ARF treated with mechanical ventilation * The patient undergoes a lung CT and EIT to guide the setting of PEEP as part of our routine clinical practice Exclusion Criteria: * The patient cannot undergo a lung CT and/or EIT as judged by the attending physician (for instance, transport to the radiology unit may be considered too risky if the patient is extremely severe, or using EIT may be contraindicated because of the presence of a pacemaker) * Pregnancy (as this condition alters the respiratory physiology)
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What it tests

  • Not listed
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Where

1 site
IRCCS Humanitas Research Hospital
Milan, Italy
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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