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โ† Trials
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A Study of CM336 in Patients With Relapsed or Refractory Autoimmune Cytopenia

RecruitingPhase 1, Phase 2Ages 18 Years - anyAllKeymed Biosciences Co.Ltd
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In plain words

What the trial is, and whether it could suit you

To evaluate the efficacy and safety of CM336 (BCMA/CD3 Bispecific Antibody) in the treatment of patients with relapsed or refractory autoimmune cytopenia

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Voluntary provision of written informed consent and ability to comply with protocol requirements. * Age โ‰ฅ18 years, male or female. * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 2. * Confirmed diagnosis of immune thrombocytopenia (ITP), warm autoimmune hemolytic anemia (wAIHA), cold agglutinin disease (CAD), mixed autoimmune hemolytic anemia (mAIHA) or Evans Syndrome. * Relapsed or refractory autoimmune hemolytic anemia. Exclusion Criteria: * Secondary ITP or AIHA caused by any reason. Subjects with positive autoimmune antibodies but without a clear diagnosis of any other autoimmune diseases are allowed to be enrolled. * Other types of AIHA or other types of cytopenia * History of critical diseases that, in the opinion of the investigator, may pose a risk to the safety of subjects or whose exacerbation during the study could compromise the efficacy or safety analysis of the results. * Received any treatment of anti-B Cell Maturation Antigen(BCMA) antibody. * Evaluated unsuitable to participant in this study by investigator.
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What it tests

  • CM336 Injection
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Where

3 sites
Henan Cancer Hospital
Zhengzhou, China
Heping Hospital Affiliated to Changzhi Medical College
Changzhi, China
Blood Disease Hospital, Chinese Academy of Medical Sciences
Tianjin, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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