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SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques

RecruitingNAAges any - anyFemaleShady Grove Fertility Reproductive Science Center
NCT07175571 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when using frozen donor sperm in people who do not have male fertility problems. The main questions it aims to answer are: Does one method create more usable embryos (blastocysts) than the other? Is there a difference in how often fertilization does not happen at all? Do either of the methods lead to better embryo quality or early pregnancy? Participants will: Have their eggs divided into two groups. One group will be fertilized using ICSI (where a sperm is injected directly into an egg), and the other using conventional IVF (where eggs are mixed with sperm in a dish). The fertilization method for each egg will be randomly assigned, with a random process also u

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female patients undergoing IVF with frozen donor sperm at Shady Grove Fertility Center * Normal ovarian reserve (AMH \> 1 ng/mL, AFC \> 10) * Absence of male factor infertility * Post-wash parameters: \>50% motility, \>5mil concentration * \> 4 oocytes retrieved at time of transvaginal oocyte retrieval Exclusion Criteria: * Donor Sperm with significant male factor infertility (e.g., abnormal sperm concentration, motility, or morphology) * Any medical condition contraindicating ART
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What it tests

  • Intracytoplasmic Sperm Injection (ICSI)
  • Conventional Insemination (IVF)
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Where

1 site
Shady Grove Fertility Rockville
Rockville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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