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Anesthesia Induced Myocardial Injury in Non-cardiac Surgery (AIMY)

Recruitingn/aAges 40 Years - 80 YearsAllUniversity Hospital Tuebingen
NCT07179029 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Myocardial injury during non-cardiac surgery (PMI) affects up to 16% of high-risk patients and represents a significant burden on healthcare systems. An acute myocardial infarction is defined by a dynamic increase in cardiac troponin (cTn) above the 99th percentile and is accompanied by clinical signs of myocardial ischemia. Myocardial injury, on the other hand, is characterized by an increase in cardiac troponin, but without meeting the diagnostic criteria for myocardial infarction. In the perioperative interval, however, it is irrelevant whether a myocardial infarction according to the universal definition or merely an increase in troponin is present, as there is no difference in mortality between the two patient groups. The comprehensive study by Botto et al. provides valuable insights into the severity of MINS and found that 8.0% of patients met the diagnostic criteria. An important

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📋 Eligibility rules (as published)
Inclusion Criteria: * Elective or emergency non-cardiac surgery * Cardiovascular risk: At least two of the following: Age \>60 years, hypertension, diabetes mellitus, coronary heart disease, peripheral arterial occlusive disease, cerebrovascular disease, chronic renal insufficiency, chronic heart failure, chronic obstructive pulmonary disease, active smoking * Age criteria: Adults aged 40-80 years. * ASA status: ASA classification II-IV. * Written consent after prior explanation Exclusion Criteria: * o Patients unable to give consent: intubated and sedated patients * Types of surgery: cardiac surgery, including coronary artery bypass grafting, heart valve repair or replacement, and heart transplantation; obstetric procedures, including cesarean section; minor surgical procedures that do not require general or regional anesthesia (e.g., minor dermatological or ophthalmological procedures) * Cardiovascular risk: patients without at least two of the following risk factors: age \<40 or \>80, no history of hypertension, diabetes, coronary artery disease, peripheral arterial disease, cerebrovascular disease, chronic renal failure, chronic heart failure, chronic obstructive pulmonary disease, and non-smoker status * Age criteria: Patients under 40 or over 80 years of age * ASA status: ASA classification of I.
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What it tests

  • Not listed
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Where

1 site
University Clinic of Tuebingen
Tübingen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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