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Adequate Hydration and Health Outcomes

RecruitingNAAges 20 Years - 65 YearsAllArizona State University
NCT07179107 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cardiovascular diseases (CVD) are the leading cause of death in middle- and high-income countries, according to data from the World Health Organization (WHO). Epidemiological studies have associated low water intake and underhydration with diabetes, chronic kidney disease, and an increased risk of CVD. Similarly, the prevalence of chronic metabolic dysfunction is increasing dramatically worldwide, becoming both a significant public health concern and a global economic burden. Reports from the WHO indicate that the number of people with diabetes worldwide has risen from 108 million in 1980 to 422 million in 2014, representing 8.5% of adults. Therefore, there is an urgent need to identify modifiable risk factors that could help prevent metabolic dysfunction and mitigate the epidemic of type 2 diabetes (T2D). Evidence suggests that the hormone arginine vasopressin (AVP) may play a key role.

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📋 Eligibility rules (as published)
Inclusion Criteria: * BMI 18.5-24.9 or 30.0-39.9 kg/m2 * HbA1c ≤7% * Age 20-65 y * available for 8 consecutive weeks same day and time Exclusion Criteria: * Diabetes * HbA1c \>7% BMI ≤18.5, BMI of 25 to \<30, or ≥ 40 kg/m2 * night shifting work * losing or gaining weight during the last 2 months (\>5 lbs. fluctuation) * thyroid medication * bariatric surgery * Habitual strenuous exercise (\>120 min/week) Strenuous exercise is defined as activities that take hard physical effort and make you breathe much harder than normal. * Construction and other workers that spend signifant portion of their work day outdoors * Commuting by bicycle * Eating disorders * Use of aspirin during the duration of the study * Cancer * Renal disease (including kidney stones or recurrent urinary track infections * Hepatic disease * Cardiac conditions * Current infection requiring medication * Chronic, contagious, infectious diseases such as tuberculosis, Hepatitis A, B, C, or HIV * Medication that could affect appetite or body weight regulation * GLP1-RA medication * Anti-depressent SSRI medication * Testosterone replacement therapy * Participating in another study at the same time * Unable to abstain from alcohol during the study * Unable to limit caffeinated beverage intake to 1 cup per day * Donated blood during the past two months * Uneasibly acessable veins * Does not have smart phone
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What it tests

  • Baseline - week 1
  • Low Water Intake - week 2
  • Moderate Water Intake - week 3
  • Adequate Water Intake - week 4
  • Washout - week 5
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Where

2 sites
850 PBC
Phoenix, United States
850 Phoenix Bioscience Core
Phoenix, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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