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Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation

RecruitingNAAges 65 Years - 85 YearsAllUniversity of Nottingham
NCT07179887 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically. Recent findings have demonsatrated efficacy in a variety of clinical settings. However, the ideal protocol of RIC \[dose\] is unknown. Dynamic Cerebral Autoregulation (dCA) has been shown to increase in response to RIC. The goal of this trial is to study whether an increase in RIC protocol intensity results in a larger effect on biomarkers of vascular health such as dCA. Participants shall: Receive RIC daily, RIC thrice weekly or sham RIC thrice weekly for 6 weeks Visit the School of Medicine at baseline and at 6 weeks for measurement of biomarkers of vascular health including blood pressure, indices od dCA and blood plasma samples

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Participant aged 65 - 85 * Participant is able to perform RIC independently at home Exclusion Criteria: * Active cardiovascular or cerebrovascular disease (acute event within the last 12 months) * Atrial fibrillation or other significant arrhythmias * Peripheral Vascular Disease * Haemostatic disorders * Soft tissue injury or fracture to the upper limb * Pregnant or breast feeding * History or current psychiatric illness * History or current neurological condition (e.g. epilepsy) * Inability to identify temporal window for transcranial doppler ultrasound at screening visit * Any condition or presentation under current investigation that is deemed by the study clinician to exclude the participant from the study. * Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
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What it tests

  • Remote Ischaemic Conditioning
  • Sham Remote Ischaemic Conditioning
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Where

1 site
School of Medicine, University of Nottingham, Royal Derby Hospital Centre
Derby, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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