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DDAVP Effect by TEG6 in Cardiac Surgery

Recruitingn/aAges 18 Years - anyAllLondon Health Sciences Centre Research Institute โ€ฆ
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In plain words

What the trial is, and whether it could suit you

Cardiopulmonary bypass (CPB) is a process that uses a pump that temporarily takes over the function of the heart and lungs during cardiac surgery to maintain blood circulation and oxygenation. Using CPB during cardiac surgery can result in complications with blood clotting. Blood clotting is achieved when molecules in the blood, called platelets, are able to form together with the help of other clotting factors to form a clot. A drug called desmopressin (DDAVP) is used to help blood clot properly by increasing the amount of clotting factors in the blood. Several studies have shown that desmopressin has the ability to reduce the amount of blood transfusions needed for cardiac surgery patients in the postoperative period. At LHSC desmopressin is frequently requested by Cardiac Surgeons and Anesthesiologists to stop bleeding and promote blood clotting where required. A test called TEG6s pla

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Age 18 years and above 2. Undergoing elective cardiac surgery with cardiopulmonary bypass 3. Able to provide informed consent Exclusion Criteria: 1. Hyponatremia 2. Allergy to desmopressin or its components 3. History of coronary artery disease with thrombosis 4. Recent history of thromboembolic events (Stroke/TIA/DVTs) 5. Severe Renal Impairment Creatinine Clearance\<30 ml/min 6. Inability to communicate in the English language
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What it tests

  • Desmopressin after protamine reversal
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Where

1 site
London Health Sciences Centre
London, Canada
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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