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SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in Children

RecruitingNAAges 3 Years - 8 YearsAllAssiut University
NCT07181967 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized split-mouth clinical trial will compare the effectiveness of 38% silver diamine fluoride (SDF) versus 5% sodium fluoride varnish (FV) in reducing salivary Streptococcus mutans levels in children with bilateral caries. Each participant will receive SDF on one side of the mouth and FV on the contralateral side. The primary outcome is change in Dentocult SM Strip Mutans scores in plaque over 3 months. Secondary outcomes include plaque index, bleeding on probing, and adverse events.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 3-8 years; cooperative (Frankl ≥2). * ≥2 contralateral primary molars with active dentin caries (ICDAS 3-5) of comparable severity. * Parent/guardian consent; child assent when appropriate. Exclusion Criteria: * Silver allergy; ulcerative gingivitis/stomatitis. * Systemic antibiotics within 4 weeks. * Fixed appliances interfering with plaque assessment. * Conditions precluding safe participation per clinician judgment.
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What it tests

  • Sodium Fluoride Varnish (5%)
  • Silver Diamine Fluoride (38%)
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Where

1 site
Assiut University
Asyut, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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