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Fentanyl vs. Remifentanil in Laparoscopic Cholecystectomy: Effects on Bowel Function and Pain

RecruitingNAAges 18 Years - 65 YearsAllKonya City Hospital
NCT07182097 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Postoperative ileus (POI) is a common complication after abdominal surgery, leading to delayed gastrointestinal recovery, prolonged hospitalization, and increased healthcare costs. Opioids, while essential for intraoperative analgesia, are known to impair bowel motility through their μ-receptor effects. Among opioids, fentanyl and remifentanil are widely used but differ in their pharmacokinetic and pharmacodynamic profiles. Remifentanil undergoes rapid metabolism, resulting in a shorter context-sensitive half-life, while fentanyl accumulates with longer infusions. Although remifentanil may theoretically have less impact on bowel recovery, its potential to induce opioid-induced hyperalgesia (OIH) and increased analgesic requirements might prolong gastrointestinal dysfunction and worsen postoperative pain outcomes. Objective: This randomized controlled trial aims to compare th

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-65 years * American Society of Anesthesiologists (ASA) physical status I or II * Scheduled for elective laparoscopic cholecystectomy * Provided written informed consent Exclusion Criteria: * Opioid use preoperatively * Previous abdominal surgery * History of ileus or gastrointestinal disease * Preoperative electrolyte imbalance * Liver or renal failure * Neuromuscular or psychiatric disorders * Known allergy to study medications * Emergency surgery * Surgical duration exceeding 90 minutes
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What it tests

  • Fentanyl 2 µg/kg IV bolus + 1-2 µg/kg/h infusion during anesthesia
  • Remifentanil 1 µg/kg IV bolus + 0.1-1 µg/kg/min infusion during anesthesia
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Where

1 site
Konya City Hospital
Karatay, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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