Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia

Inclusion Criteria: * Patients diagnosed with functional dyspepsia (FD) according to the Rome IV criteria. * Aged 18 to 80 years, regardless of gender. * Hospital Anxiety and Depression Scale (HADS) score between 8 and 14. Exclusion Criteria: * Use of probiotics or antibiotics within one month prior to the trial. * Use of psychoactive medications (including hypnotics, sedatives, anxiolytics, or antidepressants) within one month prior to the trial. * Use of hormones, immunosuppressants, or cytotoxic agents within one month prior to the trial. * Participation in any other clinical trial within one month prior to the study. * Positive test for Helicobacter pylori (Hp) infection. * Long-term use of traditional Chinese herbal medicine. * Pregnancy or lactation. * History of drug abuse. * Comorbidities such as irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), functional constipation (FC), or other significant conditions that may interfere with the trial-including severe hepatic, renal, respiratory, or autoimmune disorders; bleeding diatheses; psychiatric diseases; endocrine disorders; etc. * History of major surgery or diagnosis of diabetes mellitus. * Refusal to provide written informed consent.